Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load

Table 1 Characteristics of patients with chronic HBV infection (mean ± SD), n (%)

Characteristics	Patients (n = 422)	Clinical stage of chronic HBV infection
		Tolerant (n = 112)	Active (n = 222)	Inactive carrier (n = 88)	P
Sex (Male/female)	268/154	67/45	156/66	45/43	< 0.051
Mean age (yr)	30.59 ± 10.40	29.45 ± 11.72	29.69 ± 9.30	34.34 ± 10.53	< 0.0012
Patients with MH	233 (55.2)	93 (83.0)	115 (51.8)	25 (28.4)	< 0.0011
Age at HBV-infection (yr)					< 0.0011
< 8	166 (39.3)	62 (55.4)	92 (41.4)	12 (13.6)
8-20	127 (30.1)	33 (29.5)	80 (36.0)	14 (15.9)
> 20	103 (24.4)	9 (8.0)	46 (20.7)	48 (54.5)
Unknown	26 (6.2)	8 (6.3)	4 (1.8)	14 (15.9)
Serum ALT (IU/L)	116.52 ± 82.66	25.37 ± 12.56	161.42 ± 139.26	31.15 ± 19.67	< 0.0012
Serum AST (IU/L)	82.61 ± 79.89	22.20 ± 14.63	116.63 ± 107.84	25.29 ± 12.52	< 0.0012
Serum TBIL (&mgr;mol/mL)	15.66 ± 9.22	15.08 ± 2.55	20.78 ± 14.25	13.55 ± 11.24	< 0.0012
HBV DNA positive	285 (67.5)	112(100)	165 (74.3)	8 (9.1)	< 0.0011
Serum HBV DNA (copies/mL)					< 0.0011
≤ 1.0 × 103	137 (32.5)	0	57 (25.7)	80 (90.9)
> 1.0 × 103-1.0 × 105	46 (10.9)	6 (5.4)	32 (14.4)	8 (9.1)
> 1.0 × 105-1.0 × 107	60 (14.2)	22 (19.6)	38 (17.1)	0
> 1.0 × 107	179 (42.4)	84 (75.0)	95 (42.8)	0
HBV DNA (Log, copies/mL)	5.87 ± 2.43	7.88 ± 1.54	5.94 ± 2.21	3.11 ± 0.37	< 0.0012
HBeAg positive	218 (51.7)	112 (100)	96 (43.2)	10 (11.4)	< 0.0011
HBV pre-C region mutation positive	122 (28.9)	37 (33.0)	71 (32.0)	14 (15.9)	< 0.011

¹χ² test;

²ANOVA. HBV: Hepatitis B virus; MH: Maternal HBV-infection status.