Bile acids as endogenous etiologic agents in gastrointestinal cancer

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Jul 21, 2009 (publication date) through Nov 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2009; 15(27): 3329-3340
Published online Jul 21, 2009. doi: 10.3748/wjg.15.3329

Table 4 Bile acids induce DNA damage in colon cells

Cells/tissues	Bile acid(s)	Assay for DNA damage	Ref.
Isolated mouse colon crypt cells	LCA	Nucleoid sedimentation for strand breaks	[122]
Isolated human and rat colon cells LCA	LCA	Comet assay for strand breaks	[123]
Isolated rat colon cells	DCA	Immunostaining for poly (ADP-ribose) an indicator of DNA damage	[124]
Freshly isolated normal human colonocytes	DCA, CDCA	Comet assay for strand breaks	[125]
Cultured human adenocarcinoma cells (HT-29)	DCA, CDCA	Comet assay for strand breaks and modified comet assay for oxidative DNA damage
Cultured human adenocarcinoma cells (HT-29)	DCA, LCA	Comet assay for strand breaks	[112 126]
Cultured human adenocarcinoma cells (CACO-2)	DCA, LCA	Comet assay for oxidative DNA damage	[111]
Cultured human colon adenocarcinoma cells (HCT-116 & HCT-15)	DCA	Comet assay for strand breaks	[127]
Cultured human colon adenocarcinoma cells (HCT-116 & HT-29)	DCA	Comet assay for strand breaks	[128]
Cultured human colon adenocarcinoma cells (HCT-116)	DCA	Induction of the DNA repair protein BRCA-1	[129]
		Induction of DNA damage inducible gene GADD153	[130]
		Comet assay	[116]
Cultured human colon adenocarcinoma cells (HCT-116 and HCT-15)	DCA	Induction of DNA damage inducible genes GADD34, GADD45, GADD153	[131]
Colon samples from mouse dietary colitis model	DCA	Oxidative DNA damage: 8-OHdG assayed by immunohistochemistry	[119]

Citation: Bernstein H, Bernstein C, Payne CM, Dvorak K. Bile acids as endogenous etiologic agents in gastrointestinal cancer. World J Gastroenterol 2009; 15(27): 3329-3340
URL: https://www.wjgnet.com/1007-9327/full/v15/i27/3329.htm
DOI: https://dx.doi.org/10.3748/wjg.15.3329