Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease

doi:10.3748/wjg.15.3134

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2009; 15(25): 3134-3141
Published online Jul 7, 2009. doi: 10.3748/wjg.15.3134

Table 3 Effect of surgical interventions on serum bile acids and conjugates in CD cohorts (nmol/L)

BA class	BA/BA-conjugate	Control	No surgery	Ileocecal resection	Colectomy	Other surgery	Ileocecal resection + other surgery
Primary	CA	62.5	52.0	160.0^a^b	71.0	57.5^c	89.0^b
	TCA	23.6	0.0^a	0.0^a^b	9.5^c	8.0^c	0.0
	GCA	383.5	240.5^a	156.0^a^b	375.0^c	212.0	221.5^a
	CDCA	196.5	144.0^a	505.0^a^b	174.5	153.0	121.0
	TCDCA	230.5	81.0^a	19.0^a^b	37.5^a^b	55.5^a	17.0^a^b
	GCDCA	1446.0	848.5^a	767.0^a	1059.0	663.5^a	772.0
Secondary	DCA	239.8	90.5^a	11.0^a	6.5^a^b	17.5^a	53.0^d
	TDCA	48.2	5.9^a	0.0^a^b	0.0^a	0.0^a^b	0.0^a
	GDCA	238.6	64.0^a	0.0^a^b	0.0^a^b	0.0^a^b	43.5^a
	LCA	15.0	7.0^a	5.9^a	3.0^a	4.7^a	2.9^a
	TLCA	0.0	0.0	0.0^a^b	0.0^a^b	0.0	0.0
	GLCA¹	17.4	3.6^a	0.0^a	0.0	2.3	0.0
	UDCA	28.5	14.5^a	26.0^b	12.7	53.5	22.5
	TUDCA	0.0	0.0	0.0^a	0.0^a	0.0^a	0.0^a
	GUDCA¹	137.9	95.2^a	59.7	92.1	323.5	75.6
Tertiary	HDCA	0.0	27.0^a	10.0^a	9.5^a	9.0^a	2.0^a
	THDCA	0.0	0.0^a	0.0	0.0	0.0	0.0
	GHDCA¹	0.0	0.0	0.0	0.0	2.0	0.0

Control: n = 310; No surgery: n = 64, n = 31¹; Ileocecal resection: n = 41, n = 16¹; Colectomy: n = 22, n = 8¹; Other surgery: n = 12, n = 4¹; Ileocecal resection + other surgery: n = 12, n = 9¹. Data expressed as medians.

^aP < 0.05 vs control,

^bP < 0.05 vs no surgery,

^cP < 0.05 vs ileocecal resection,

^dP < 0.05 vs colectomy (Mann-Whitney U test).

Citation: Gnewuch C, Liebisch G, Langmann T, Dieplinger B, Mueller T, Haltmayer M, Dieplinger H, Zahn A, Stremmel W, Rogler G, Schmitz G. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J Gastroenterol 2009; 15(25): 3134-3141
URL: https://www.wjgnet.com/1007-9327/full/v15/i25/3134.htm
DOI: https://dx.doi.org/10.3748/wjg.15.3134