Survival predictors in patients treated with a molecular adsorbent recirculating system

doi:10.3748/wjg.15.3015

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Jun 28, 2009 (publication date) through Feb 14, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2009; 15(24): 3015-3024
Published online Jun 28, 2009. doi: 10.3748/wjg.15.3015

Table 3 Changes in laboratory parameters during MARS treatment in different liver failure subgroups

	Before MARS	After MARS	Percent change	P	Before MARS	After MARS	Percent change	P	Before MARS	After MARS	Percent change	P
	Toxic ALF (n = 63)				Unknown-cause ALF (n = 41)				Other ALF (n = 9)
Hemoglobin g/L	110 (77-170)	100 (59-136)	-9	< 0.001	110 (74-146)	98 (71-134)	-11	0.001	98 (80-131)	88 (82-120)	-10	NS
Leucocytes 10⁹/L	8.6 (1.0-29.2)	8.7 (2.4-33.9)	1	NS	8.9 (2.8-21.9)	8.4 (2.9-42.5)	-6	NS	7.6 (2.6-41)	11.4 (1.7-30.6)	50	NS
Platelets 10⁹/L	130 (11-438)	80 (9-349)	-38	< 0.001	140 (48-511)	74 (25-327)	-47	< 0.001	97 (37-248)	85 (19-184)	-12	0.04
CRP g/L	9 (5-157)	15 (5-186)	67	< 0.001	8 (5-120)	10 (5-142)	25	0.006	30 (5-331)	33 (5-148)	10	NS
Creatinine &mgr;mol/L	79 (35-1318)	51 (17-585)	-35	< 0.001	84 (36-572)	54 (17-337)	-36	< 0.001	85 (57-567)	53 (23-149)	-38	0.02
Urea mmol/L	4.8 (0.8-31.2)	1.7 (0.2-11.7)	-65	< 0.001	6.3 (1.0-25.6)	1.8 (0.8-58)	-71	< 0.001	12.0 (4.2-29.3)	4.3 (1.0-6.7)	-64	0.01
NH₄-ion &mgr;mol/L	75 (18-512)	55 (3.5-258)	-26	< 0.001	75 (24-244)	56 (20-309)	-25	0.006	81 (8-317)	45 (17-176)	-45	NS
Bilirubin &mgr;mol/L	84 (4-761)	97 (6-355)	15	0.05	472 (35-725)	301 (10-570)	-36	< 0.001	372 (62-694)	190 (94-348)	-49	NS
AST U/L	842 (15-24360)	282 (15-5240)	-67	< 0.001	427 (50-18140)	183 (19-4080)	-57	< 0.001	600 (37-12640)	83 (43-2227)	-86	NS
ALT U/L	1120 (11-12500)	565 (5-9970)	-50	< 0.001	550 (71-11946)	174 (33-7790)	-68	< 0.001	217 (22-6710)	171 (21-1321)	-21	0.04
γ-GT U/L	72 (8-2139)	55 (9-1279)	-24	0.01	106 (20-503)	49 (5-238)	-54	< 0.001	157 (21-1422)	62 (22-1010)	-61	NS
FV %	33 (5-201)	51 (5-149)	55	0.07	33 (5-119)	23 (7-101)	-33	NS	55 (7-100)	53 (26-127)	-3	NS
AT3 %	44 (15-125)	41 (15-122)	-6	0.002	26 (15-78)	27 (15-68)	4	NS	32 (19-110)	33 (18-92)	3	NS
TT (%)	22 (6-80)	30 (6-112)	36	NS	17 (6-44)	18 (6-68)	3	NS	26.5 (6-53)	36 (16-52)	36	NS
INR	2.5 (1.1-7.7)	2 (1.0-9.9)	-20	NS	3.1 (1.5-9.9)	2.8 (1.5-10)	-10	NS	2.3 (1.4-5.5)	1.8 (1.4-3)	-22	NS
	Alcohol-related AOCLF (n = 45)				Other AOCLF (n = 17)				Graft failure (n = 11)
Hemoglobin g/L	101 (59-129)	94 (75-123)	-7	0.01	96 (71-130)	91 (75-104)	-5	NS	96 (86-117)	99 (71-123)	3	NS
Leucocytes 10⁹/L	17.2 (5-39.3)	16.7 (2.1-45.7)	-3	NS	10 (1.4-30.7)	5.7 (1.3-30)	-43	0.01	9.5 (1.7-14.9)	8.8 (2.1-20.8)	-7	NS
Platelets 10⁹/L	129 (15-508)	83 (6-349)	-36	< 0.001	82 (27-238)	57 (19-215)	-30	0.004	81 (27-453)	83 (16-206)	2	NS
CRP g/L	32 (5-110)	38 (5-160)	19	NS	35 (5-67)	38 (5-110)	9	0.01	22 (6-172)	23 (9-64)	5	NS
Creatinine &mgr;mol/L	167 (49-686)	65 (20-216)	-61	< 0.001	210 (29-325)	52 (17-149)	-75	< 0.001	159 (39-301)	70 (22-121)	-56	0.003
Urea mmol/L	17.5 (1.8-56.5)	3.5 (0.7-18.3)	-80	< 0.001	16.9 (3.2-27.4)	3.1 (1.2-12.3)	-82	< 0.001	16.5 (6.0-32.3)	4.7 (1.3-10.0)	-72	0.004
NH₄-ion &mgr;mol/L	73 (12-311)	60 (23-144)	-18	0.05	89 (19-223)	62 (21-96)	-30	0.03	47 (17-177)	32 (25-69)	-32	NS
Bilirubin &mgr;mol/L	513 (17-840)	271 (14-499)	-47	< 0.001	481 (278-909)	283 (134-530)	-41	0.001	311 (107-720)	223 (74-348)	-28	0.009
AST U/L	156 (27-4540)	140 (13-1959)	-10	0.002	210 (31-1230)	144 (58-1222)	-31	0.03	321 (27-12560)	226 (53-87380)	-30	NS
ALT U/L	74 (9-2904)	69 (8-2480)	-7	< 0.001	100 (18-681)	85 (27-286)	-16	0.07	722 (38-9460)	4400 (48-25120)	509	NS
γ-GT U/L	198 (29-1086)	147 (19-810)	-26	< 0.001	69 (19-429)	61 (12-342)	-12	NS	180 (26-2385)	174 (34-1619)	-3	NS
FV %	53 (8-125)	46 (8-131)	-12	< 0.001	34 (7-124)	26 (8-124)	-24	0.005	79 (7-131)	77 (13-107)	-3	NS
AT3 %	34 (13-88)	29 (15-67)	-13	0.001	29 (15-100)	23 (15-100)	-21	0.01	54 (15-137)	56 (17-104)	-4	NS
TT (%)	22 (9-135)	17 (6-49)	-23	0.02	20 (6-96)	17 (6-73)	-15	NS	42 (8-139)	47 (20-113)	-12	NS
INR	2.4 (1.3-5.6)	2.9 (1.3-9.9)	21	0.03	2.4 (1-8.5)	2.9 (1.1-8.5)	21	0.01	1.5 (0.9-6.4)	1.5 (1.0-2.8)	0	NS

All laboratory values are expressed as median (range). NH₄-ion: Ammonium ion (normal range: 36-86 mmol/L); AST: Aspartate aminotransferase; γ-GT: gamma glutamyltransferase; FV: Coagulation factor V (normal range: 80%-120%); AT3: Antithrombin III (normal range 80%-120%); TT (%): Thrombin time (normal range, 70%-130%) (includes coagulation factors II, VII, X).

Citation: Kantola T, Koivusalo AM, Parmanen S, Höckerstedt K, Isoniemi H. Survival predictors in patients treated with a molecular adsorbent recirculating system. World J Gastroenterol 2009; 15(24): 3015-3024
URL: https://www.wjgnet.com/1007-9327/full/v15/i24/3015.htm
DOI: https://dx.doi.org/10.3748/wjg.15.3015