Role of scintigraphy in inflammatory bowel disease

Table 1 Summary of published studies evaluating the use of Tc-99m HMPAO WBC in IBD

Study	n	Study design	Sensitivity	Specificity
Adult population
Sciarretta et al[23]	103	Known active CD compared with colonoscopy	95%	100%
Mairal et al[50]	27	Known IBD compared with In-111 HIG	100%	85%
Giaffer et al[13]	31	Suspected IBD compared with In-111 oxine labeled leukocytes	85% at 40 min 94% at 120 min	87% at 40 min 71% at 120 min
Kolkman et al[33]	32	Known IBD compared with CT	79% for CD 81% for UC	98% for CD 86% for UC
Molnár et al[34]	28	Known active CD compared with spiral CT	76.1%	91%
Almer et al[25]	48	Known active CD with small bowel inflammation compared with intraoperative small bowel enteroscopy and laparotomy findings	85%	81%
Pediatric population
Charron et al[40]	215	Acute intestinal inflammation in patients with and without IBD	90%	97%
Cucchiara et al[38]	48	Suspected IBD compared with colonoscopy	76.2%	NA
Charron et al[42]	130	Exclude inflammation in suspected IBD compared with colonoscopy	94%	99%
Alberini et al[37]	28	Known IBD compared with endoscopy, ultrasonography and contrast radiology	75%	92%
Charron et al[35]	313	Known IBD compared with colonoscopy	92%	94%

NA: Not applicable; CD: Crohn’s disease; CT: Computed tomography; IBD: Inflammatory bowel disease; UC: Ulcerative colitis.