Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma

Table 6 mRNA expression and clinical data of WIF-1 in HCC and adjacent non-cancerous tissues (mean ± SE)

Clinical data	Case	The mRNA expression of WIF-1 in HCC	t	P	The mRNA expression of WIF-1 in adjacent non-cancerous tissues	t	P
Sex
Male	27	0.882 ± 0.542	0.942	0.365	0.828 ± 0.320	0.286	0.783
Female	6	0.720 ± 0.336			0.787 ± 0.318
Age (yr)
< 60	12	0.767 ± 0.397	1.092	0.289	0.793 ± 0.247	0.551	0.589
≥ 60	21	0.985 ± 0.643			0.862 ± 0.407
Child
A	29	0.854 ± 0.543	0.067	0.948	0.793 ± 0.309	1.243	0.286
B	4	0.845 ± 0.171			1.015 ± 0.337
AFP (ng/mL)
< 20	19	0.873 ± 0.516	0.231	0.819	0.828 ± 0.377	0.148	0.883
≥ 20	14	0.831 ± 0.519			0.812 ± 0.247
Number of tumor
Single	24	0.927 ± 0.532	1.292	0.212	0.801 ± 0.288	0.496	0.630
Multiple	9	0.704 ± 0.408			0.872 ± 0.393
Tumor diameter (cm)
< 3	5	1.002 ± 0.750	0.507	0.636	0.796 ± 0.415	0.147	0.889
≥ 3	28	0.826 ± 0.469			0.825 ± 0.304
HBsAg
(+)	29	0.875 ± 0.527	0.155	0.886	0.838 ± 0.312	0.754	0.497
(-)	4	0.820 ± 0.681			0.695 ± 0.360
Hepatocirrhosis
(+)	25	0.840 ± 0.523	0.260	0.797	0.810 ± 0.322	0.331	0.746
(-)	8	0.893 ± 0.486			0.853 ± 0.314
False capsule
(+)	28	0.860 ± 0.490	0.152	0.886	0.816 ± 0.296	0.144	0.892
(-)	5	0.812 ± 0.676			0.846 ± 0.454
Tumor thrombus
(+)	3	0.815 ± 0.505	1.392	0.276	0.806 ± 0.319	0.840	0.474
(-)	30	1.223 ± 0.481			0.960 ± 0.300
Edmonson stage
I/II	28	0.910 ± 0.517	1.005	0.083	0.821 ± 0.308	0.141	0.894
III	5	0.532 ± 0.360			0.848 ± 0.401