Promoter methylation and mRNA expression of DKK-3 and WIF-1 in hepatocellular carcinoma

Table 5 mRNA expression and clinical data of DKK-3 in HCC and adjacent non-cancerous tissues (mean ± SE)

Clinical data	Case	The mRNA expression of DKK-3 in HCC	t	P	The mRNA expression of DKK-3 in adjacent non-cancerous tissues	t	P
Sex
Male	27	0.776 ± 0.346	0.153	0.880	0.779 ± 0.319	0.888	0.404
Female	6	0.761 ± 0.168			0.913 ± 0.338
Age (yr)
< 60	20	0.756 ± 0.356	0.334	0.741	0.819 ± 0.341	0.195	0.847
≥ 60	13	0.795 ± 0.285			0.840 ± 0.274
Child
A	29	0.761 ± 0.331	0.789	0.466	0.829 ± 0.329	0.171	0.869
B	4	0.863 ± 0.225			0.813 ± 0.155
AFP (ng/mL)
< 20	17	0.716 ± 0.287	1.069	0.294	0.840 ± 0.354	0.124	0.902
≥ 20	16	0.835 ± 0.384			0.826 ± 0.281
Number of tumor
Single	24	0.740 ± 0.315	0.971	0.348	0.823 ± 0.298	0.262	0.797
Multiple	9	0.860 ± 0.329			0.860 ± 0.377
Tumor diameter (cm)
< 3	4	0.908 ± 0.300	0.943	0.399	0.792 ± 0.352	0.290	0.780
≥ 3	29	0.755 ± 0.322			0.841 ± 0.315
HBsAg
(+)	29	0.660 ± 0.233	0.984	0.372	0.817 ± 0.304	0.639	0.563
(-)	4	0.789 ± 0.329			0.955 ± 0.418
Hepatocirrhosis
(+)	25	0.780 ± 0.319	0.046	0.964	0.761 ± 0.268	2.157	0.057
(-)	8	0.774 ± 0.365			1.060 ± 0.361
False capsule
(+)	28	0.757 ± 0.326	1.750	0.132	0.819 ± 0.307	0.790	0.466
(-)	5	1.014 ± 0.299			0.966 ± 0.395
Tumor thrombus
(+)	3	0.770 ± 0.330	0.738	0.519	0.811 ± 0.307	1.088	0.379
(-)	30	0.890 ± 0.260			1.057 ± 0.379
Edmonson stage
I/II	28	0.807 ± 0.335	3.380	0.020	0.820 ± 0.317	0.564	0.596
III	5	0.586 ± 0.350			0.910 ± 0.333