Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment: A single-center analysis

Table 4 Time-related changes by period analysis n (%)

	First period (Jan 1994-Jan 2000)	Second period (Feb 2000-Jan 2006)	P
Patients (male:female)	93 (63:30)	143 (90:53)	NS
Age (yr) (mean, range)	63.9 (40-81)	62.5 (36-81)	NS
1-yr survival rate	88.3%	85.6%	NS
1-yr recurrence rate	38.5%	44%	NS
Anesthetic risk
ASA I-II	60 (64.5)	90 (62.9)	NS
ASA III-IV	33 (35.5)	53 (37.1)	NS
Number nodules	1.77 (1-6)	2.3 (1-11)	0.012
Size of nodules	3.8 (0.8-11)	3 (0.2-12)	NS
Bilobar disease	19 (20.4)	57 (39.9)	0.002
Extrahepatic disease	1 (1.1)	10 (7)	0.03
Preoperative CEA level (ng/dL)	13.5 (0.4-3203)	8.9 (0.6-1715)	0.03
Adjuvant treatment to CLM	13 (14)	49 (34.3)	0.001
Resectability rate	69.9%	86.7%	0.002
Use of intraoperative US	91.3%	92.9%	NS
Concordance of IOUS	56.5%	67.9%	NS
Procedures performed			0.024
Major hepatectomy	23 (35.4)	28 (22.6)
Minor hepatectomy	18 (27.7)	48 (38.7)
Atypical hepatectomy	17 (26.2)	20 (16.1)
Combined hepatectomy	7 (10.8)	28 (22.6)
Operative time (min)	226.7 ± 58.8	251 ± 65.3	0.01
Blood loss (mL)	440 (25-1700)	560 (80-2500)	NS
Need of transfusion	40%	44.7%	NS
Complications rate	32.3%	60.5%	0.001
Minor complications	24.6%	54%	0.001
Major complications	7.7%	5.6%	NS
Postoperative stay (d)	11 (5-34)	9 (4-43)	0.018
Postoperative mortality	1.5%	1.6%	NS
Complementary treatment of CLM	60%	49.2%	NS