Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer

Table 2 Clinicopathological features of gastric cancer and methylation of CHFR

Variable	Negative	Methylated	P value
	n= 39	n= 20
Gender
Male	26	11	NS
Female	13	9
Age	60.5	64.6	NS
Histology
Intestinal	14	10	NS
Diffuse	25	10
Serosal invasion
Negative	15	8	NS
Positive	24	12
Histological lymph node metastasis
Negative	15	5	NS
Positive	24	15
Vascular involvement
Negative	22	14	NS
Positive	14	6
Peritoneal dissemination
Negative	32	17	NS
Positive	7	3
Stage
I + II	12	5	NS
III + IV	27	15
p53 mutation
Wild	33	18	NS
Mutation	6	2
MIN status
MSI-H/L	3	7	< 0.01
MSS	36	13

NS: Not significant.