Relationship between angiotensin-(1-7) and angiotensin II correlates with hemodynamic changes in human liver cirrhosis

Table 2 Circulating RAS components in healthy controls, MLD and ALD patients

RAS components	Healthy controls	MLD	ALD
PRA (ng Ang I/ mL per hour)	0.10 (0.03-0.23)	0.10 (0.01-0.22)	2.7 (0.43-6.61)ac
Ang I (pg/mL)	179.8 (86.9-220.8)	28.9 (23-65.2)a	412.3 (326.5-1123)ac
Ang II (pg/mL)	47.0 (41.8-61.7)	27.5 (23.9-35.9)a	84.4 (60.9-154.6)ac
Ang-(1-7) (pg/mL)	20.1 (17.1-25.5)	24.9 (21.1-27.4)	32.6 (27.8-61.6)a

Data are expressed as medians (25 and 75 percentile).

^aP < 0.05 for the comparison of MLD and ALD groups with healthy controls and

^cP < 0.05 for the comparison between MLD and ALD groups (Kruskal-Wallis followed by Dunn test). PRA: Plasma renin activity; Ang: Angiotensin.