Current prophylactic strategies against hepatitis B virus recurrence after liver transplantation

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May 28, 2009 (publication date) through Nov 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2009; 15(20): 2489-2499
Published online May 28, 2009. doi: 10.3748/wjg.15.2489

Table 2 Prevention of HBV recurrence after LT with LAM and low-dose IM HBIG

Authors	Patients (n)	DNA+ prior to LT (%)	Pretransplant LAM therapy (%)	Duration of pretransplant LAM therapy (mean mo)	DNA+ at LT (%)	Prophylactic protocol after LT	Follow-up (mean mo)	Recurrence(%)
Jiao et al[90]	79	47	28	0.5	0	LAM + HBIG IM¹	29	2.5
Gane et al[91]	147	85	NA	3	< 50	LAM + HBIG IM²	61	4
Zheng et al[77]	114	NA	13	5	31	LAM + HBIG IM³	16	14
Karademir et al[92]	35	51	40	6	14	LAM + HBIG IM⁴	16	5.7
Angus et al[93]	32	97	100	3.2	NA	LAM + HBIG IM⁵	18.4	3.1

NA: Not available.

¹2000 IU (IM) at LT, 800 IU (IM) daily for 6 d, weekly for 3 wk, then aim for anti-HBs > 100 IU/L;

²800 IU (IM) at LT and daily for 6 d, then 800 IU (IM) monthly;

³2000 IU (IM) at LT, 800 IU (IM) daily for 6 d, weekly for 3 mo, and then monthly;

⁴4000 IU (IM) at LT, 2000 IU (IM) daily until anti-HBs > 200 IU/L, then aim for > 100 IU/L;

⁵800 IU (IM) at LT and daily for 1 wk, then 800 IU (IM) monthly.

Citation: Jiang L, Jiang LS, Cheng NS, Yan LN. Current prophylactic strategies against hepatitis B virus recurrence after liver transplantation. World J Gastroenterol 2009; 15(20): 2489-2499
URL: https://www.wjgnet.com/1007-9327/full/v15/i20/2489.htm
DOI: https://dx.doi.org/10.3748/wjg.15.2489