Review
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. May 28, 2009; 15(20): 2489-2499
Published online May 28, 2009. doi: 10.3748/wjg.15.2489
Table 1 ADV monotherapy vs ADV/LAM combination therapy in patients with lamivudine-resistant chronic hepatitis B
Ref.Patients (n)
Undetectable HBV DNA
Follow up
PNormalization of ALT
Follow up
PADV resistance
Follow-up
P
AALA (%)AL (%)A (%)AL (%)A (%)AL (%)
[36]14287989At month 36 0.267391At month 24 0.69210At month 36 0.020
[37]23368289At month 24> 0.505379At month 24> 0.50220At month 24 0.001
[38]28286440At month 24 0.388074At month 12 0.72187At month 24 0.940
[39]34368297At month 12> 0.507996At month 12> 0.50183At month 12> 0.500