Features of hepatocellular carcinoma in cases with autoimmune hepatitis and primary biliary cirrhosis

Table 3 Clinical status of reported cases of hepatocellular carcinoma associated with autoimmune hepatitis and primary biliary cirrhosis, compared to cases of general hepatocellular carcinoma in Japan

Clinical status	Compiled numbers (%)			P-values
	HCC patients with AIH (AIH-series)	HCC patients with PBC (PBC-series)	General-HCC patients	AIH-series/General-HCC patients	PBC-series/General-HCC patients	AIH-series/PBC-series
History of blood transfusion	Total: 29	Total: 38	Total: 12602	P = 0.040a	P = 0.581	P = 0.041a
+	3 (10.3)	13 (34.2)	3633 (28.8)
-	26 (89.7)	25 (65.8)	8969 (71.2)
History of excessive alcohol intake	Total: 38	Total: 50	Total: 14694	P = 0.812	P = 0.056	P = 0.352
+	1 (2.6)	5 (10.0)	3271 (22.3)
-	37 (97.4)	45 (90.0)	11423 (77.7)
Co-infection	Total: 33	Total: 40	Total: 4121
HBV (prior) +	2 (6.1)	10 (25.0)	2138 (51.9)	P < 0.001	P <0.001	P = 0.025
HBV (prior) –	31 (93.9)	30 (75.0)	1983 (48.1)
Co-infection	Total: 38	Total: 49	Total:16492
HCV +	3 (7.9)	10 (20.4)	11488 (69.7)	P < 0.001	P < 0.001	P = 0.044
HCV -	35 (92.1)	39 (79.6)	5004 (30.3)
Pathological findings of noncancerous lesion of the liver	Total: 31	Total: 44	Total: 4941	P = 0.163	P = 0.007b	P = 0.489
NL, CH, LF	13 (41.9)	15 (34.1)	2691 (54.5)
LC	18 (58.1)	29 (65.9)	2250 (45.5)

HCC: Hepatocellular carcinoma; AIH: Autoimmune hepatitis; PBC: Primary biliary cirrhosis; HBV: Hepatitis B virus; HCV: Hepatitis C virus; NL: Normal liver; CH: Chronic hepatitis; LF: Liver fibrosis; LC: Liver cirrhosis.