Features of hepatocellular carcinoma in cases with autoimmune hepatitis and primary biliary cirrhosis

Table 2 Analysis on gender and age of reported cases of hepatocellular carcinoma associated with autoimmune hepatitis and primary biliary cirrhosis, compared to cases of general hepatocellular carcinoma in Japan

	Compiled numbers (%)			P-values
Clinical status	HCC patients with AIH (AIH-series)	HCC patients with PBC (PBC-series)	General-HCCpatients	AIH-series/General-HCC patients	PBC-series/General-HCC patients	AIH-series/PBC-series
Gender
Actual number	Total: 38	Total: 50	Total: 16743
Male	7 (18.4)	13 (26.0)	12025 (71.8)
Female	31 (81.6)	37 (74.0)	4718 (28.2)	P = 0.1491	P = 0.5121	P = 0.244
Relative number	Total: 38	Total: 50
Male	23.3 (61.3)	38.0 (76.0)
Female	14.7 (38.7)	12.0 (24.0%)
Age at HCC diagnosis	Total: 38	Total: 50	Total: 16743
(mean ± SD)	(67.61 ± 8.58)	(68.54 ± 9.30)	NA
< 40 s	0 (0)	2 (4.0)	761 (4.6)	NA	NA	P = 0.410
50 s	8 (21.0)	6 (12.0)	2818 (16.8)			(P = 0.614)
60 s	16 (42.1)	21 (42.0)	6179 (36.9)
70 s	9 (23.7)	14 (28.0)	5976 (35.7)
< 80 s	5 (13.2)	7 (14.0)	1009 (6.0)

The P-value above was calculated from the Mann-Whitney U-test and the P-value below, indicated in parentheses, was calculated from the F-test.

¹The P-value was calculated from the relative numbers. HCC: Hepatocellular carcinoma; AIH: Autoimmune hepatitis; PBC: Primary biliary cirrhosis; SD:Standard deviation; NA: Not available.