Role of bacterial and genetic factors in gastric cancer in Costa Rica

Table 6 Adjusted odd ratios with 95% confidence intervals and P-value for combinations of host and bacterial factors according to gastric cancer in Costa Rican H pylori-positive patients

Combination of factors	Gastric Cancer
	Pos/Neg	OR (95% CI)	P-value
IL-1&bgr;+3954_T/C, IL-1RN*2/L, IL-10-592_C/A
Pos	10/8	4.7 (1.7-13.0)	0.002
Neg	42/183
IL-1&bgr;+3954_T/C, IL-1RN*2/L, IL-10-592_C/A, vacA s1b/m1
Pos	9/2	7.2 (1.4-36.4)	0.017
Neg	40/74
IL-1&bgr;+3954_T/C, IL-1RN*2/L, vacA s1b/m1
Pos	18/4	9.8 (2.9-32.9)	< 0.001
Neg	31/72
IL-1RN*2/L, IL-10-592_C/A, vacA s1b/m1
Pos	14/9	3.0 (1.1-8.1)	0.028
Neg	35/67
IL-1&bgr;+3954_T/C, IL-10-592_C/A, vacA s1b/m1
Pos	21/9	4.7 (1.9-11.9)	0.001
Neg	28/67