Role of bacterial and genetic factors in gastric cancer in Costa Rica

Table 3 Statistical analysis for several cytokine gene polymorphisms according to high gastric cancer incidence rate and gastric cancer in H pylori-positive Costa Rican patients

	High GCIR			Gastric cancer
	Pos/Neg	OR (95% CI)	P-value	Pos/Neg	OR (95% CI)	P-value
Interleukin-1&bgr;-511
T/T	28/19	1.9 (0.8-4.3)	0.136	18/47	1.6 (0.7-4.1)	0.283
T/C	50/43	1.4 (0.7-2.8)	0.317	24/93	1.2 (0.5-2.9)	0.629
C/C	23/28	1.0 reference		10/51	1.0 reference
Interleukin-1&bgr;+3954
T/T	2/0	-	-	-	0/2	-
T/C	56/45	1.4 (0.8-2.6)	0.237	39/101	2.1 (1.0-4.3)	0.049
C/C	43/45	1.0 reference		13/88	1.0 reference
Interleukin-1RN intron 2
*2/*2	20/11	2.2 (0.9-5.2)	0.078	4/31	0.7 (0.2-2.2)	0.494
*2/L	31/28	1.2 (0.6-2.3)	0.592	33/59	3.5 (1.7-7.3)	0.001
L/L	50/51	1.0 reference		15/101	1.0 reference
Interleukin-10-1082
A/A	52/49	1.3 (0.3-6.1)	0.766	35/101	3.2 (0.3-30.2)	0.304
G/A	46/37	1.6 (0.3-7.8)	0.551	16/83	1.8 (0.2-17.1)	0.617
G/G	3/4	1.0 reference		1/7	1.0 reference
Interleukin-10-592
A/A	11/12	0.7 (0.3-1.7)	0.406	10/23	3.1 (1.2-8.2)	0.022
C/A	34/31	0.9 (0.5-1.6)	0.668	26/65	3.2 (1.5-6.8)	0.002
C/C	56/47	1.0 reference		16/103	1.0 reference

-: Unable to compute. Pos: Positive; Neg: Negative.