Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer

Figure 2 Immunodetection of hepatic microsomal CYP isoforms from DEN- and/or CXB-treated rats. Microsomal proteins (15 and 30 &mgr;g/lane for CYP2B1/2 and CYP1A1, respectively) were separated by SDS-PAGE and tested for different CYPs using specific anti-rat CYP antibodies. The bands in the inset box correspond to CYP2B1/2 and CYP1A1 protein detected in the NT, DEN and DEN+CXB groups. The graphic represents the densitometric analysis of the CYP amounts in the experimental groups. ^aP < 0.05, vs NT group; ^cP < 0.05 vs DEN group, Bonferroni test. n = 4 for all groups.