Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males

Table 2 ORs and their 95% CIs for esophageal cancer with reference to ALDH2 and ADH2 polymorphisms

	Controls n (%)	Cases n (%)	OR1 (CI)	OR2 (CI)
ALDH2 genotype
G/G	90 (40.73)	114 (59.69)	1.00	1.00
G/A	89 (40.27)	66 (34.55)	1.71 (1.10-2.66)	1.70 (1.08-2.68)
A/A	42 (19.00)	11 (5.96)	4.84 (2.25-10.61)	5.69 (2.51-12.18)
G/A+A/A	131 (59.27)	77 (40.51)	2.15 (1.43-3.26)	2.19 (1.43-3.34)
ADH2 genotype
A/A	106 (47.96)	108 (56.54)	1.00	1.00
A/G	96 (43.44)	75 (39.27)	1.30 (0.85-1.99)	1.21 (0.79-1.86)
G/G	19 (8.60)	8 (4.19)	2.42 (1.02-5.77)	2.78 (1.06-7.29)
A/G+G/G	115 (52.04)	83 (43.46)	1.41 (0.96-2.08)	1.34 (0.89-2.04)
Allele frequencies
ALDH2
G	269 (60.86)	294 (76.96)	1.00
A	173 (39.14)	88 (23.04)	2.15 (1.57-2.95)
ADH2
A	308 (69.68)	291 (76.18)	1.00
G	134 (30.32)	91 (23.82)	1.39 (1.01-1.92)

¹Crude OR;

²Adjusted odds ratios (ORs) were adjusted for income.