Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma

Table 1 Correlation between CD133 and CD24 expression and clinicopathological factors in colorectal cancer (n = 523)

	n	Expression of CD133		Pvalue	Expression of CD24		Pvalue
		Negative (n = 395)	Positive (n = 128)	(χ2-test)	Negative (n = 259)	Positive (n = 264)	(χ2-test)
Age (yr)				0.431			0.999
< 59	261	201	60		129	132
≥ 59	262	194	68		130	132
Gender				0.002			0.261
Male	295	208	87		140	155
Female	228	187	41		120	108
Tumor location				0.735			0.315
Right colon	133	99	34		71	62
Left colon	390	296	94		189	201
Tumor size				0.436			0.658
< 5.5 cm	254	188	66		124	130
≥ 5.5 cm	269	207	62		136	133
T category				0.0241			0.219
Tis	12	12	0		8	4
T1	9	8	1		4	5
T2	37	29	8		20	17
T3	452	337	115		223	229
T4	13	9	4		5	8
N category				0.890			0.525
N0	234	178	56		113	121
N1	132	96	36		65	67
N2	157	121	36		81	76
M category				0.555			0.482
M0	502	378	124		248	254
M1	21	17	4		12	9
AJCC stage				0.259			0.998
0	12	12	0		8	4
I	34	29	5		18	16
IIA, IIB	185	134	51		85	100
IIIA, IIIB, IIIC	271	203	68		137	134
IV	21	17	4		12	9
Dukes’ stage				0.560			0.515
A	17	16	1		10	7
B1, B2	210	157	53		98	112
C1, C2	275	205	70		139	136
D	21	17	4		12	9
Degree of differentiation				0.084			0.0061
Well	23	16	7		10	13
Moderate	393	300	93		183	210
Poorly	100	74	26		61	39
Undifferentiated	7	5	2		5	2
Lymphatic invasion				0.848			0.772
Absent	225	169	56		110	115
Present	298	226	72		150	148
Vascular invasion				0.740			0.508
Absent	513	387	126		254	259
Present	10	8	2		6	4

¹χ² test for linear trend. AJCC: American Joint Committee on Cancer; CD: Cluster of differentiation.