Non-invasive assessment of liver fibrosis in chronic liver diseases: Implementation in clinical practice and decisional algorithms

Table 6 Combinations of serum parameters for non-invasive diagnosis of liver fibrosis

Marker	Description	Settings in which validation exists	Ref.
AST/ALT	AST to ALT ratio	HCV, HBV	[6364657172]
APRI	AST to platelets ratio index	HCV, HBV, HIV/HCV	[64–7275–80]
Forns’ index	Age, BMI, γGT, cholesterol	HCV, HBV, HIV/HCV	[67697275]
Fibrotest	Age, gender, α-2-macroglobulin, γGT, haptoglobin, apolipoprotein A1, total bilirubin	HCV, HBV, ALD, NAFLD, HIV/HCV	[6567727680]
ELF	Age, hyaluronic acid, type III procollagen, TIMP1	HCV, ALD, NAFLD	[6062]
Hepascore	Bilirubin, γGT, hyaluronic acid, α-2-macroglobulin, age, sex	HCV	[5859]
Lok index	AST, ALT, platelets, INR	HCV	[68]
Fibroindex	AST, platelets, g-globulins	HCV	[7172]
Fibrometer	Age, AST, platelets, hyaluronan, INR, α-2-macroglobulin, urea	HCV	[5556]
Fibrospect	α-2-macroglobulin, hyaluronan, TIMP1	HCV	[57]
Fib-4	Age, AST, ALT, platelets	HCV, HBV, HIV/HCV	[73–75]

APRI: AST-to platelet ratio index; ELF: European liver fibrosis study group.