Non-invasive assessment of liver fibrosis in chronic liver diseases: Implementation in clinical practice and decisional algorithms

Table 11 Comparison of the performance of SAFE biopsy[6794], Fibropaca algorithm[96] and Leroy algorithm[97]. Results are expressed as percentages

	SAFE biopsy for diagnosis of		Fibropaca algorithm for diagnosis of		Leroy algorithm for diagnosis of ≥ F2
	≥ F2	F4	≥ F2	F4
APRI needed	100	100	100	100	100
Forns needed	0	0	100	0	0
Fibrotest needed	41.7	57.6	100	100	100
Sensitivity	100	81.8	85.5	72.7	89.6
Specificity	78.2	92.4	89.9	96.7	97.8
Accuracy	90	91.2	87.6	94	93.5
Saved biopsies	43.8	79.1	51.7	76.2	29.2

≥ F2: Significant fibrosis; F4: Cirrhosis; APRI: AST-to-platelet ratio index.