Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode

Figure 2 PCNA expression by hepatic cells in the liver from five patients with AE (immunohistochemical analysis). A: Hepatic cells close to the parasitic lesions were strongly labeled by the anti-PCNA antibody; all cells with a dark-brown/black nucleus are positive cells; some of them indicated by an arrow (initial magnification: × 20); B: Hepatic cells distant from the parasitic lesions did not express PCNA (initial magnification: × 20); C: Quantitative expression of PCNA was significantly higher in the liver cells close to the parasitic lesions than in those distant to them (^aP < 0.05).