Involvement of 90-kuD ribosomal S6 kinase in collagen type I expression in rat hepatic fibrosis

Figure 1 Co-immunofluoresence of p90RSK and collagen type I in fibrotic liver and normal liver. Sections (A-C) are from rat liver with intraperitoneal injection of DMN for 3 wk, and sections (D-F) are from normal livers as control. Sections of fibrotic liver mostly demonstrate that collagen type I (rhodamine) and p90RSK (FITC) immunoreactivity were both present around central veins as well as in the interstitium, and up-regulated in fibrotic liver. Sections of normal liver mostly demonstrate that collagen type I (rhodamine) immunoreactivity was less in normal liver than in fibrotic liver and p90RSK (FITC) was hardly observed in nomal liver simultaneously.