Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

Figure 5 FXR loss of function sensitizes mice to CCl₄-induced liver fibrosis. A: Sirius red staining of liver section obtained from FXR +/+ mice; B: Sirius red staining of liver section obtained from FXR -/- mice; C: Sirius red staining of liver section obtained from FXR +/+ mice treated with CCl₄; D: Sirius red staining of liver section obtained from FXR -/- mice treated with CCl₄; E: Liver section stained with CSE monoclonal antibody obtained from FXR +/+ mice; F: Liver section stained with CSE monoclonal antibody obtained from FXR -/- mice; G: Liver section stained with CSE monoclonal antibody obtained from FXR +/+ mice treated with CCl₄; H: Liver section stained with CSE monoclonal antibody obtained from FXR -/- mice treated with CCl₄.