High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells

Figure 3 Impact of miR-196a on cellular signaling, in vitro chemosensitivity and in vivo induction of lung metastases. A: miR-196a transfection activates the AKT pathway but does not impact on the MEK pathway; B: miR-196a transfection significantly increases chemosensitivity towards oxaliplatin and cisplatin but not towards 5-FU or irinotecan; C: miR-196a significantly promoted growth of lung metastases in a xenograft biosystem after tail-vein injection and 7 wk of incubation.