Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

Table 2 Effect of loss of FXR on liver injury induced by 12 administrations of CCl₄ (6 wk)

	AST (U/L)	ALT (U/L)	Bilirubin (mg/dL)
FXR +/+ naive	127 ± 15	48 ± 8	0.015 ± 0.001
FXR +/+ CCl4	250 ± 40a	369 ± 35a	0.118 ± 0.004a
FXR -/- naive	143 ± 10	79 ± 25a	0.068 ± 0.004a
FXR -/- CCl4	740 ± 230ce	354 ± 137c	0.252 ± 0.02ce

Data are mean ± SD of six mice.

^aP < 0.05 vs FXR +/+ control mice;

^cP < 0.05 vs FXR -/- control mice;

^eP < 0.05 vs CCl₄ FXR +/+ mice.