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©2009 The WJG Press and Baishideng.
World J Gastroenterol. Apr 14, 2009; 15(14): 1708-1718
Published online Apr 14, 2009. doi: 10.3748/wjg.15.1708
Published online Apr 14, 2009. doi: 10.3748/wjg.15.1708
Table 4 Overview of function, source and involvement of the 10 genes identified by Pubmed-search: Degree of up- or down-regulation
Gene | Fold change | Biological function | Primary cell source | Involvement | Reference |
Acetyl-Coenzyme A synthetase 2 | 9.61 | Mitochondrial matrix enzyme involved in CoA ligation | Mitochondrial matrix | Activation during fasting | [5051] |
HM GCS1 | 5.81 | Cholesterol biosynthesis | Inhibition induces apoptosis, up-regulation involved in liver regeneration | [2526] | |
RBP4 | 5.76 | An a2-globulin that transports vitamin A from the liver | Parenchymal liver cells, little in Kupffer cells | Known marker for hepatocellular necrosis | [2223] |
Inter-alpha trypsin inhibitor, heavy chain 2 | 5.46 | Plasma protease inhibitor | Kupffer cells | Endothelial growth factor | [27–29] |
Lipocalin 2 | 5.35 | Iron-siderophore-binding protein | Macrophages, neutrophils | Suppression of inflammation, tissue involution, apoptosis, differentiation of myeloid cells | [31–40] |
Hck | -5.67 | Protein-tyrosine kinase | Granulocytes, monocytes | Mitogenesis, differentiation, survival, migration | [41–44] |
Leucine-rich repeat-containing 5 | -6.26 | Interaction with cellular G-proteins | Enzyme inhibition, cell adhesion, cellular trafficking, proliferation and activation of lymphocytes and monocytes | [4552] | |
Myristoylated alanine rich protein kinase C substrate | -7.14 | Substrate of protein kinase C | Intracellular signaling, brain development, cellular migration and adhesion, phagocyte activation, phagocytosis | [464753–55] | |
Heterogeneous nuclear ribonucleoprotein A/B | -7.94 | Chromatin-associated RNA-binding protein | Ubiquitious | RNA handling, proliferation arrest | [5657] |
(SCAN-KRAB-) zinc finger gene 1 | -9.05 | Protein interaction domain | Ubiquitious | Cell survival, differentiation | [4849] |
- Citation: Gehring S, Sabo E, Martin MES, Dickson EM, Cheng CW, Gregory SH. Laser capture microdissection and genetic analysis of carbon-labeled Kupffer cells. World J Gastroenterol 2009; 15(14): 1708-1718
- URL: https://www.wjgnet.com/1007-9327/full/v15/i14/1708.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.1708