Oral allopurinol to prevent hyperamylasemia and acute pancreatitis after endoscopic retrograde cholangiopancreatography

Table 2 Procedural details, endpoints and post-ERCP morbidity n (%)

	Allopurinol group n = 85	Placebo group n = 85	P
Procedural details
Total procedural time (min)	37.8 ± 11.9	38.2 ± 12.4	0.82
Cannulation time (min)	15.4 ± 5.5	15.6 ± 5.6	0.81
Pancreatic cannulation and injection	24 (24.7)	18 (21.1)	0.18
Number of injections	1.23 ± 0.42	1.27 ± 0.44	0.60
Acinarization	9 (10.5)	9 (10.5)	0.58
Invasive diagnostics
Cytology	15 (17.6)	17 (20)	0.42
Intrabiliary biopsy	2 (2.3)	2 (2.3)	0.69
Therapeutics
Any Therapeutics	71 (83.5)	74 (87)	0.51
Precut sphincterotomy	15 (17.6)	18 (21.1)	0.56
Biliary sphincterotomy	20 (23.5)	17 (20)	0.57
Stone extraction	29 (34.1)	27 (31.7)	0.74
Biliary stenting	32 (37.6)	37 (43.5)	0.43
Pancreatic stenting	2 (2.3)	3 (3.5)	0.64
End points
Hyperamylasemia	5 (5.8)	18 (21.1)	0.003
Pancreatitis	2 (2.3)	8 (9.4)	0.049
PEP in low-risk procedures	1/55 (1.8)	1/57 (1.7)	0.70
PEP in high-risk procedures	1/30 (3.3)	7/28 (25)	0.02
ERCP morbidity
Bleeding	2 (2.3)	2 (2.3)	0.69
Perforation	1 (1.1)	0	0.50