Efficacy of tricyclic antidepressants in irritable bowel syndrome: A meta-analysis

Table 3 Response to treatment

Study	Definition of response	Response		Change in abdominal pain score (No. of patients)
		TCA	Placebo	TCA	Placebo
Vahedi et al[16], 2008	Complete loss of symptoms (total score= 0) at the end of the study or at least two scores with a decrease in the number of symptoms	17/25	10/25	-	-
Talley et al[17], 2008	Adequate relief of IBS symptoms over 50% of the weeks	10/18	9/16	-45.3 ± 26.3 (18)	-7.4 ± 46.9 (16)
Morgan et al[18], 2005	Improvement of IBS symptoms determined by patients	13/22	5/22	-	-
Rajagopalan et al[19], 1998	Global well-being: patients were asked to estimate at the post-treatment interview how much better or worse they were on the whole (in percentage) as compared to the pretrial period	7/11	3/11	-	-
Vij et al[20], 1991	Improvement of 50% or above in IBS symptoms	11/21	5/23	-	-
Greenbaum et al[21], 1987	Global assessment of improvement	15/28	5/28	-58.96 ± 19.37 (28)	-13.93 ± 17.76 (28)
Tripathi et al[22], 1983	Improvement of 50% or above in IBS symptoms	7/25	4/25	-	-