Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population

Table 3 Distribution of genotypes for IL-1β (-511 and -31), IL-1RN and TNF-α in the control group and in patients with gastrointestinal pathologies n (%)

Genotypes	Control	Gastritis	DU	GU	AC
	n= 100	n= 80	n= 33	n= 34	n= 30
IL-1β-31
T/T	9	3 (4)	1 (3)	2 (6)	1 (4)
C/T	23	21 (26)	9 (27)	7 (20)	4 (13)
C/C	68	56 (70)	23 (70)	25 (74)	25 (83)
P value		NS	NS	NS	NS
IL-1β-511
C/C	31	26 (33)	9 (27)	10 (29)	6 (20)
C/T	46	34 (42)	13 (39)	14 (41)	11 (37)
T/T	23	20 (25)	11 (34)	10 (30)	13 (43)
P value		NS	NS	NS	NS
IL-1RN
1/1	58	41 (51)	15 (46)	11 (32)	10 (33)
1/2	36	34 (43)	16 (49)	21 (62)	19 (63)
2/2	6	5 (6)	2 (6)	2 (6)	1 (4)
P value		NS	NS	0.00	0.00
TNF-α
G/G	86	62 (77)	23 (70)	29 (85)	24 (80)
G/A	13	16 (20)	8 (24)	4 (12)	5 (16)
A/A	1	2 (3)	2 (6)	1 (3)	1 (4)
P value		NS	NS	NS	NS

DU: Duodenal ulcer; GU: Gastric ulcer; AC: Adenogastric carcinoma; G Test: Control versus disease; NS: Not significant.