Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats

Table 2 Effect of melatonin on serum ALT, AST levels and A/G value in different groups (mean ± SD)

Group	Dose (mg/kg)	n	ALT (U/L)	AST (U/L)	A/G
Normal	-	11	70.00 ± 35.27	139.82 ± 72.83	0.94 ± 0.40
Model	-	13	286.23 ± 121.91b	431.00 ± 166.35b	0.74 ± 0.09
NAC	100	12	194.42 ± 90.83bc	293.33 ± 94.60bc	0.78 ± 0.11
MEL	2.5	11	211.09 ± 97.03b	357.09 ± 153.26b	0.68 ± 0.15
	5	13	201.15 ± 101.16bc	321.23 ± 162.48bc	0.77 ± 0.15
	10	12	178.67 ± 103.14bd	292.42 ± 126.23bc	0.73 ± 0.07

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; A: Albumin; G: Globumin.

^bP < 0.01 vs normal control group;

^cP < 0.05 vs model control group;

^dP < 0.01 vs model control group.