Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats

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Mar 28, 2009 (publication date) through Jul 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2009; 15(12): 1452-1458
Published online Mar 28, 2009. doi: 10.3748/wjg.15.1452

Table 1 Pathologic grading of hepatic fibrosis in different groups

Group	Dose (mg/kg)	n	Pathologic grading of hepatic fibrosis					u value
	Dose (mg/kg)		0	I	II	III	IV
Normal	-	11	11	0	0	0	0	5.5681^b
Model	-	13	0	0	1	6	6	-
NAC	100	12	0	2	5	3	2	1.8838
MEL	2.5	11	0	2	4	2	3	1.5568
	5	13	0	2	4	3	4	1.3662
	10	12	0	4	4	1	3	2.1720^a

u represents the Ridit value of the two groups, P < 0.05 indicates u > 1.96; P < 0.01 indicates u > 2.58;

^aP < 0.05,

^bP < 0.01 vs model group.

Citation: Hong RT, Xu JM, Mei Q. Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol 2009; 15(12): 1452-1458
URL: https://www.wjgnet.com/1007-9327/full/v15/i12/1452.htm
DOI: https://dx.doi.org/10.3748/wjg.15.1452