Curcumin suppresses PPARδ expression and related genes in HT-29 cells

Figure 5 Curcumin inhibited β-catenin association with Tcf-4 and down-regulated the β-catenin/Tcf reporter activities in HT-29 cells. A: Immunoprecipitation and immunoblotting results showed that curcumin inhibited β-catenin associated with Tcf-4 but had no effects on the level of β-catenin in nucleus; B: Curcumin significantly reduced TOPflash luciferase activity but had no effect on the activity of FOPflash. Values represent means ± SE of three independent experiments. (^aP < 0.05 vs control; ^bP < 0.01 vs control).