Alcohol-induced protein hyperacetylation: Mechanisms and consequences

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Mar 14, 2009 (publication date) through Jan 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2009; 15(10): 1219-1230
Published online Mar 14, 2009. doi: 10.3748/wjg.15.1219

Table 4 Histone acetyltransferases expressed in the liver

Family	HAT	In liver? (methods)	Location	Substrates	References
Gcn5/PCAF	PCAF	Yes (IB)	Nucleus Cytoplasm	Histones, p53, PGC-1a, other transcription factors, cortactin	[52–58]
p300/CBP	CBP	Yes (IB)	Nucleus	Histones, E1A, p53, SRC-1, TIF2, ACTR, SREBP, other transcription factors	[54 57 58]
	p300	Yes (IB)	Nucleus	Histones, E1A, p53, SRC-1,TIF2, TAT, ACTR, SREBP, other transcription factors	[18 54 55 57 58]
MYST	TIP60	Yes (IB)	Nucleus Cytoplasm	Histones H3 and H4, androgen receptor	[54 57]
	HBO	Unknown	Nucleus	Histones H3 and H4	[57 58]
	MOZ	No	Nucleus	Histones H3 and H4	[100]
	MORF	Yes (RT-PCR)	Nucleus	Histones H3 and H4	[101 102]

E1A: Adenovirus early region 1A; SRC-1: Steroid receptor coactivator; TIF2: Transcriptional intermediary factor 2.

Citation: Shepard BD, Tuma PL. Alcohol-induced protein hyperacetylation: Mechanisms and consequences. World J Gastroenterol 2009; 15(10): 1219-1230
URL: https://www.wjgnet.com/1007-9327/full/v15/i10/1219.htm
DOI: https://dx.doi.org/10.3748/wjg.15.1219