Impact of asialoglycoprotein receptor deficiency on the development of liver injury

Table 1 Changes in ALT activity, TUNEL positive cells, AST activity, caspase 3 activity, collagen content, IL-6 content, MDA content and α-SMA content in RD mice compared to WT mice

Challenge	RD mice compared to WT mice
Alcohol	Liver TUNEL-positive hepatocytes
Anti-Fas	Liver TUNEL-positive hepatocytes
	Serum ALT
	Serum AST
	Liver caspase 3 activity
	Collagen deposition in extracellular matrix
	Fibronectin deposition in the extracellular matrix
CCl4	Liver TUNEL-positive hepatocytes
	Serum ALT
	Serum AST
	Liver MDA content
	Liver α-SMA content
LPS/galactosamine	Liver TUNEL-positive hepatocytes
	Serum ALT
	Serum AST
	Liver caspase 3 activity
	Serum IL-6 content

ALT: Alanine transaminase; AST: Aspartate transaminase; IL-6: Interleukin 6; MDA: Malondialdehyde; α-SMA: α-smooth muscle actin; RD: Receptor-deficient; WT: Wild-type. The various conditions the mice were challenged with were alcohol (Lieber de-Carli ethanol diet for 7 d), anti-Fas (0.2 &mgr;g/g body weight), CCl₄ (1 mL/kg body weight) and LPS/galactosamine (50 &mgr;g LPS/kg body weight and 350 mg galactosamine/kg body weight).