In vitro and in vivo models of acute alcohol exposure

Table 1 The characteristics of in vitro and in vivo models of AAA

AAA model	Advantages	Disadvantages	Area of research
In vitro	Low cost Technically easy to perform Large number of experimental groups Pure cell populations Single cell type or multi-cell type co-culture Strictly controlled settings yielding reproducible results	Limited alcohol metabolism Limited complexity at cellular and tissue levels Limited areas of research, not suitable for behavioral and social studies.	Behavioral and biomedical
In vivo	Availability of physiological routs of alcohol administration Complex interactions of all bodily organs and systems, including complex metabolism Controlled settings, caloric and composition controls Indications to individual and population variability	Ethical concerns High cost Limited information about the effect on one separate cell population.	All areas of research including biomedical, behavioral and social.