Iron homeostasis and H63D mutations in alcoholics with and without liver disease

Table 1 Clinical and laboratory characteristics of LDA and NLDA

	LDA (n = 78)	NLDA (n = 75)	P value
Age (yr)	52.3 ± 10.1	48.5 ± 10.7	0.03
Number of men (%)	66 (85)	62 (83)	NS
Alcohol consumption (g/d)	217 ± 195	327 ± 311	0.004
Presence of ascitis (%)	38 (52.1)	-	-
Presence of encephalopathy (%)	17 (34.7)	-	-
Alanine aminotransferase (r.v. 0-37 IU/L)	53 ± 60	17 ± 6	< 0.05
Aspartate aminotransferase (r.v. 0-41 IU/L)	81 ± 128	15 ± 5	< 0.05
Alkaline phosphatase (r.v. 40-129 IU/L)	143 ± 75	91 ± 21	< 0.05
γ-Glutamil transpeptidase (r.v. 8-61 IU/L)	225 ± 239	47 ± 48	< 0.05
Albumin (g/L)	36 ± 8	43 ± 3	< 0.05
Bilirubin (mg/dL)	4.0 ± 7.2	0.7 ± 0.9	< 0.05
Prothrombin time (seconds prolonged from control)	3.2 ± 2.7	0.5 ± 1.2	< 0.05
Cholesterol (mg/dL)	160.0 ± 84	209.1 ± 41.7	< 0.05
Triglycerides (mg/dL)	125.6 ± 111.3	162.8 ± 121.0	NS
Glucose (mg/dL)	119.9 ± 40.5	97 ± 13.6	NS
Iron (r.v. 65-175 &mgr;g/dL)	115 ± 64	99.4 ± 39	NS
TIBC (r.v. 250-425 &mgr;g/dL)	241 ± 88	279 ± 40	0.001
Transferrin saturation (%)	51 ± 27	36 ± 13	< 0.001
Ferritin (r.v. 23-236 ng/mL)	559 ± 607	159 ± 122	< 0.001

r.v.: Reference value; TIBC: Total iron binding capacity.