Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males

Table 5 Probability ratios for the combinations of ALDH2, ADH2 and CYP2E1 genotypes and the amount of alcohol consumed, n (%)

Alcohol drinking	Genotype	Cases (n = 80)	Controls (n = 480)	OR (95% CI)	OR (95% CI)
ALDH2
Never/rare	1/1	7 (8.8)	72 (15.0)	1
-to-light	1/2	7 (8.8)	180 (37.5)	0.56 (0.20-1.59)
	2/2	0 (0.0)	33 (6.9)	0.00 (NC)
Moderate	1/1	30 (37.5)	180 (37.5)	2.29 (0.94-5.57)
-to-heavy	1/2	36 (45.0)	15 (3.1)	8.58 (3.28-22.68)	3.12 (1.86-6.58)
ADH1B
Never/rare	1/2+2/2	13 (16.3)	273 (56.9)	1
-to-light	1/1	1 (1.3)	12 (2.5)	1.00 (0.18-9.22)
Moderate	1/2+2/2	50 (62.5)	183 (38.1)	4.75 (2.53-9.38)
-to-heavy	1/1	16 (20.0)	12 (2.5)	27.12 (8.52-70.19)	5.48 (1.98-14.55)
CYP2E1
Never/rare		5 (6.3)	189 (39.4)	1
-to-light	c1/c1	9 (11.3)	96 (20.0)	0.56 (0.20-1.59)
Moderate	c1/c2+	18 (22.5)	96 (20.0)	1.93 (0.43-2.41)
-to-heavy	c2/c2
	c1/c1	48 (60.0)	99 (20.6)	7.64 (2.82-11.31)	5.32 (1.62-9.28)