Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males

Table 1 Polymorphisms in the CYP2E1, ALDH2 and ADH1B genes

Locus	Gene	Subunit	Nucleotide	Effect	RFLP
/protein			change
ADH1B	ADH2*1	β1		Wild-type
	ADH2*2	β2	48G>A	His48;
				(earlier as His47)
ALDH2	ALDH2*1			Wild-type
	ALDH2*2		1510G>A	Lys487
CYP2E1	CYP2E1*1A		None	Wild type	Pst I-/Rsa I +
					(c1allele)
	CYP2E1*5B		-1293G>C;		Pst I+/Rsa I -
					(c2 allele)
			-1053C>T

CYP2E1 allele nomenclature, http://www.imm.ki.se; NIAAA publications, http://pubs.niaaa.nih.gov.