Intestinal permeability and its association with the patient and disease characteristics in Crohn’s disease

Table 3 Relationship between intestinal permeability (log LMR) and characteristics of the patients and disease (n = 125)

Variables	n	Mean LMR (95% CI)	P value
Gender
Males	66	0.036 (0.029, 0.046)	0.0024a
Females	59	0.022 (0.0178, 0.028)
Area of involvement of the GI tractb
Small intestine only (L1)	16	0.028 (0.0175, 0.0447)	0.0001a
Large Intestine only (L2)	62	0.021 (0.0174, 0.0255)
Ileo-colonic (L3)	47	0.0451 (0.0336, 0.0605)
UGI Involvement
Absent	102	0.0268 (0.0224, 0.0321)	0.0406a
Present	23	0.0416 (0.027, 0.062)
Perianal disease
Absent	100	0.028 (0.023, 0.033)	0.3573
Present	25	0.0339 (0.0234, 0.049)
Behavior of the diseased
Non-fistulizing Non-stricturing (B1)	74	0.024 (0.0194, 0.0298)	0.0062a
Stricturing (B2)	37	0.043 (0.032, 0.058)
Fistulizing (B3)	14	0.028 (0.018, 0.042)
Extra intestinal manifestations
Absent	76	0.028 (0.0226, 0.034)	0.5674
Present	49	0.030 (0.0236, 0.040)

Values are expressed as geometric mean (95% CI),

^aP < 0.05; Large intestine only vs ileo-colonic,

^bP = 0.001 < 0.01; Non-fistulizing non-stricturing vs stricturing,

^dP = 0.004 < 0.01.