Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma

Table 6 Multivariate analysis for recurrence-free and overall survivals in 57 patients who did not meet the criteria

Factor	Covariate (n)	Reference (n)	Recurrence-free survival			Overall survival
			HR	95% CI	P	HR	95% CI	P
Gender	Female (13)	Male (44)	1.35	0.56-3.25	0.50	2.35	0.90-6.17	0.08
Number of tumor	Multiple (28)	Single (29)	0.84	0.32-2.25	0.73	0.72	0.24-2.20	0.57
Histology	Poor1 (16)	Well-mod2 (39)	1.14	0.47-2.76	0.76	0.61	0.21-1.73	0.35
Vascular invasion	Present (18)	Absent (38)	2.97	1.17-7.58	0.02	3.92	1.38-11.24	0.01
Stage by LCSGJ3	III + IV (38)	I+II (19)	1.65	0.57-4.78	0.36	1.92	0.52-7.09	0.33
AFP (ng/mL)	≥ 20 (35)	< 20 (22)	1.58	0.59-4.22	0.36	1.85	0.52-6.54	0.34
DCP (mAU/mL)	≥ 400 (27)	< 400 (30)	0.79	0.35-1.79	0.58	2.29	0.35-2.29	0.83

n: Number of patients; HR: Hazard ratio; CI: Confidence interval.

¹Poorly differentiated;

²Well or moderately differentiated hepatocellular carcinoma;

³LCSGJ: Liver Cancer Study Group of Japan.