Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma

Table 5 Multivariate analysis for recurrence-free and overall survivals in 85 patients who met the criteria

Factor	Covariate (n)	Reference (n)	Recurrence-free survival			Overall survival
			HR	95% CI	P	HR	95% CI	P
Number of tumor	Multiple (8)	Single (77)	0.66	0.06-7.45	0.74	0.46	0.006-35.08	0.72
Histology	Poor1 (10)	Well-mod2 (68)	0.70	0.24-2.01	0.51	0.37	0.07-2.12	0.27
Vascular invasion	Present (8)	Absent (75)	1.04	0.44-2.46	0.93	0.96	0.31-2.99	0.95
Stage by LCSGJ3	III + IV (9)	I+II (76)	1.90	0.17-21.28	0.60	3.97	0.05-333.33	0.53
AFP (ng/mL)	≥ 20 (52)	< 20 (33)	1.28	0.71-2.29	0.41	1.20	0.54-2.66	0.66
DCP (mAU/mL)	≥ 400 (11)	< 400 (74)	3.32	1.20-9.17	0.02	1.20	2.98-50.00	0.0005

n: Number of patients; HR: Hazard ratio; CI: Confidence interval.

¹Poorly differentiated;

²Well or moderately differentiated hepatocellular carcinoma;

³LCSGJ: Liver Cancer Study Group of Japan.