Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma

Table 3 Multivariate analysis for recurrence-free and overall survivals in 142 patients undergoing hepatectomy for hepatocellular carcinoma

Factor	Covariate (n)	Reference (n)	Recurrence-free survival			Overall survival
			HR	95%CI	P	HR	95% CI	P
Number of tumor	Multiple (36)	Single (106)	0.93	0.39-2.23	0.87	0.82	0.29-2.35	0.71
Size of tumor (cm)	> 5 (85)	≤ 5 (57)	0.93	0.51-1.82	0.82	1.00	0.41-2.42	1.00
Histology	Poor1 (26)	Well-mod2 (107)	1.14	0.63-2.05	0.67	0.73	0.33-1.61	0.44
Vascular invasion	Present (20)	Absent (113)	1.68	0.99-2.86	0.05	2.02	1.07-3.83	0.03
Stage by LCSGJ3	III+IV (47)	I+II (85)	1.72	0.73-2.69	0.22	2.24	0.78-6.45	0.13
AFP (ng/mL)	≥ 20 (87)	< 20 (55)	1.36	0.83-2.22	0.23	1.55	0.81-2.97	0.18
DCP (mAU/mL)	≥ 400 (38)	< 400 (104)	1.45	0.78-2.69	0.24	2.44	1.15-5.21	0.02

n: Number of patients; HR: Hazard ratio; CI; Confidence interval.

¹Poorly differentiated;

²Well or moderately differentiated hepatocellular carcinoma;

³LCSGJ: Liver Cancer Study Group of Japan.