COOH-terminal deletion of HBx gene is a frequent event in HBV-associated hepatocellular carcinoma

Table 2 Patterns of genomic integrated HBV DNA in HCC tissues by Southern blot

Gene probes	n	Tumor					Non-tumor liver tissues
		I	R	I + R	Total	%	I	R	I + R	Total	%
HBV-DNA	44	16	0	9	25	56.8	10	5	8	23	52.3
(EcoR I restriction)
HBV-DNA	44	18	0	7	25	56.8	13	6	4	23	52.3
(Hind III restriction)
HBx-DNA	44	13	0	7	20	45.0	8	4	6	18	40.9
(EcoR I restriction)
HBc-DNA	44	16	0	6	22	50.0	9	5	5	19	43.2
(EcoR I restriction)
Pre-S	44	16	0	9	25	56.8	10	5	7	22	50.0
(EcoR I restriction)

I: Integrated pattern; R: Replicated pattern, I + R: Integrated coexistence with replicated (mixed pattern).