COOH-terminal deletion of HBx gene is a frequent event in HBV-associated hepatocellular carcinoma

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Mar 7, 2008 (publication date) through Feb 4, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Mar 7, 2008; 14(9): 1346-1352
Published online Mar 7, 2008. doi: 10.3748/wjg.14.1346

Table 1 Sequences of HBx integrated with Homo sapiens chromosomal 17 nucleotide sequences in 8 HCC cases

Case No.	Homo sapiens chromosome 17, clone RP11-104H15 (PCR sequencing)			HBV gene
Case No.	A	B	C	HBV gene
2	chromosome 14	56455-56249	56194-56158	1957-1976
	(39-87)	(224-430)	(485-521)	(514-533)
3	56677-56472	56455-56249	56194-56158	1957-1976
	(1-206)	(223-429)	(484-520)	(513-532)
4	56663-56472	56455-56249	56194-56158	1957-1976
	(1-192)	(209-415)	(470-506)	(499-518)
5	56676-56472	56455-56249	56194-56158	1957-1976
	(1-205)	(222-428)	(483-519)	(512-531)
8	56675-56472	56455-56249	56194-56158	1957-1976
	(6-208)	(225-431)	(486-522)	(515-534)
13	56679-56472	56455-56249	56194-56158	1957-1976
	(1-208)	(225-431)	(486-522)	(515-534)
15	56669-56472	56455-56249	56194-56158	1957-1976
	(1-198)	(215-421)	(476-512)	(505-524)
16	56675-56472	56455-56249	56194-56158	1957-1976
	(1-204)	(221-427)	(482-518)	(511-530)

A, B and C represent 3 discontinuated sequences at 17p13 and integrated HBV gene sequences.

Citation: Liu XH, Lin J, Zhang SH, Zhang SM, Feitelson MA, Gao HJ, Zhu MH. COOH-terminal deletion of HBx gene is a frequent event in HBV-associated hepatocellular carcinoma. World J Gastroenterol 2008; 14(9): 1346-1352
URL: https://www.wjgnet.com/1007-9327/full/v14/i9/1346.htm
DOI: https://dx.doi.org/10.3748/wjg.14.1346