Sources of calcium in agonist-induced contraction of rat distal colon smooth muscle in vitro

Figure 1 Ca²⁺ influx through SOCCs in enzymatically dissociated smooth muscle cells of rats distal colon. After depletion of the SR by thapsigargin in the absence of extracellular Ca²⁺, subsequent rapid reintroduction of extracellular Ca²⁺ resulted in activation of CCE via SOCCs. CCE were insensitive to verapamil, but blocked by La³⁺. ^bP < 0.01 vs control.