Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B

Table 3 Multiple linear regression predicting peripheral blood T lymphocyte subpopulations (n = 206)

	CD3+ T lymphocyte			CD4+ T lymphocyte			CD8+ T lymphocyte			CD4+/CD8+ ratio
	β	SE	P value	β	SE	P value	β	SE	P value	β	SE	P value
Intercept	69.39	3.51		35.6	2.07		23.21	2.56		1.55	0.12
Serum HBV load (Log, copies/mL)1	-2.58	0.45	< 0.0001	-1.31	0.26	< 0.0001	2.05	0.33	< 0.0001	-0.11	0.02	< 0.0001
HBeAg2	2.37	1.65	0.15	0.71	0.98	0.47	-1.16	1.21	0.34	0.06	0.06	0.32
Liver diseases status3			< 0.01			0.63			0.04			0.04
Moderate-CHB	-0.36	1.58		-1.15	0.93		2.34	1.15		-0.15	0.05
Severe-CHB	-6.14	1.88		-1.65	1.11		3.52	1.37		-0.14	0.06
Age at HBV-infection (yr)4			0.31			< 0.001			0.06			< 0.001
8-20	-0.06	2.09		4.1	1.24		-0.72	1.52		0.13	0.07
> 20	-1.72	2.55		4.03	1.51		-0.16	1.86		0.15	0.09
Unknown	1.93	4.94		6.17	2.92		-0.52	3.61		0.14	0.17
Maternal HBV-infection status5	3.61	2.05	0.08	1.78	1.21	0.14	-2.76	1.49	0.07	0.14	0.07	0.05

β: Coefficients from the model.

¹Continuous variable;

²Reference group: HBeAg-negative;

³Reference group: mild-CHB;

⁴Reference group: < 8 yr old age at HBV infection;

⁵Reference group: With maternal HBV-infection status.