Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B

Table 2 Peripheral T-cell subsets in normal control and CHB patients broken down by various factors (mean ± SD)

Groups	n	CD3+	CD4+	CD8+	CD4+/CD8+ ratio
HBV statusb
Negative (normal control)	100	71.07 ± 4.76	38.94 ± 3.39	24.02 ± 4.35	1.67 ± 0.33
Positive	206	55.44 ± 12.39	30.92 ± 7.48	34.39 ± 9.22	1.01 ± 0.49
Maternal HBV-infection statusb
Negative	102	60.36 ± 10.68	34.92 ± 6.52	30.43 ± 7.76	1.25 ± 0.49
Positive	104	50.60 ± 12.09	26.99 ± 6.18	38.29 ± 8.91	0.77 ± 0.34
Age at HBV-infection (yr)d
< 8	86	49.83 ± 11.64	25.74 ± 5.16	39.11 ± 8.68	0.70 ± 0.24
8-20	71	59.28 ± 11.47	34.15 ± 6.31	31.49 ± 7.52	1.18 ± 0.47
> 20	45	60.29 ± 11.13	35.58 ± 7.27	29.68 ± 8.80	1.33 ± 0.54
Unknown	4	53.20 ± 12.45	32.63 ± 4.43	37.78 ± 5.54	0.88 ± 0.19
Liver diseases statusd
Mild-CHB	101	60.38 ± 11.51	33.57 ± 8.36	30.29 ± 8.91	1.23 ± 0.54
Moderate-CHB	54	56.69 ± 10.27	30.53 ± 4.79	35.26 ± 7.72	0.93 ± 0.31
Severe-CHB	51	44.32 ± 8.71	26.08 ± 5.19	41.63 ± 6.18	0.65 ± 0.19
HBV DNA load (copies/mL)f
≤ 1.0 × 103	57	66.13 ± 7.38	37.92 ± 5.94	25.18 ± 5.39	1.58 ± 0.43
> 1.0 × 103-1.0 × 105	32	60.93 ± 8.02	32.73 ± 6.42	33.18 ± 5.36	1.03 ± 0.33
> 1.0 × 105-1.0 × 107	31	54.28 ± 12.91	29.63 ± 7.07	35.17 ± 8.18	0.88 ± 0.25
> 1.0 × 107	86	46.72 ± 9.31	26.07 ± 4.52	40.69 ± 7.35	0.67 ± 0.22
HBeAg statusb
Negative	110	61.09 ± 10.67	33.99 ± 7.48	30.17 ± 8.04	1.24 ± 0.52
Positive	96	48.99 ± 11.06	27.39 ± 5.75	39.24 ± 8.05	0.73 ± 0.25

^bP < 0.001 for all comparisons of +ve vs -ve for each measure and each T-cell parameter;

^dP < 0.01,

^fP < 0.001 for ANOVA Linear trend test.