Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B

Table 1 Characteristics of patients with chronic hepatitis B

Characteristics	All patients	Various courses of chronic hepatitis B
	(n = 206)	Mild-CHB (n = 101)	Moderate-CHB (n = 54)	Severe-CHB (n = 51)	P value
Sex (male/female)	143/63	68/33	36/18	39/12	> 0.052
Mean age (yr)1	29.61 ± 9.38	29.06 ± 9.88	29.72 ± 9.16	30.59 ± 8.67	> 0.053
Patients with MH, n (%)	104 (50.5)	45 (44.6)	23 (42.6)	36 (70.6)	< 0.012
Age at HBV-infection (yr), n (%)					< 0.012
< 8	86 (41.7)	34 (33.7)	22 (40.7)	30 (58.8)
8-20	71 (34.5)	39 (38.6)	22 (40.7)	10 (19.6)
> 20	45 (21.8)	28 (27.7)	8 (14.8)	9 (3.9)
unknown	4 (1.9)	0	2 (3.7)	2 (3.9)
Serum ALT (IU/L)1	163.75 ± 140.41	69.91 ± 17.36	152.04 ± 19.62	379.65 ± 186.44	< 0.0013
Serum AST (IU/L)1	116.69 ± 107.97	52.61 ± 14.13	96.26 ± 21.27	265.25 ± 125.12	< 0.0013
Serum total bilirubin (&mgr;mol/mL)1	20.79 ± 14.02	15.18 ± 2.42	19.20 ± 4.51	33.59 ± 23.22	< 0.0013
HBV DNA positive, n (%)	149 (72.3)	51 (50.5)	47 (87.0)	51 (100.0)	< 0.0012
Serum HBV DNA (copies/mL), n (%)					< 0.0012
≤ 1.0 × 103	57 (27.7)	50 (49.5)	7 (13.0)	0
> 1.0 × 103-1.0 × 105	32 (15.5)	14 (13.9)	18 (33.3)	0
> 1.0 × 105-1.0 × 107	31 (15.0)	11 (10.9)	11 (20.4)	9 (17.6)
> 1.0 × 107	86 (41.7)	26 (25.7)	18 (33.3)	42 (82.4)
HBV DNA load (Log, copies/mL)1	5.84 ± 2.22	4.77 ± 2.11	5.91 ± 1.83	7.91 ± 1.17	< 0.0013
HBeAg positive, n (%)	96 (46.6)	25 (24.8)	31 (57.4)	40 (78.4)	< 0.0012

HBV: Hepatitis B virus; CHB: Chronic hepatitis B; MH: Maternal HBV-infection status.

¹Date are expressed as mean ± SD;

²Chi-square test P-value;

³ANOVA P-value.