The blind men ‘see’ the elephant-the many faces of fatty liver disease

Figure 2 It is interesting to note that adipose tissue, liver and immunocytes has same ancestor-the “fat body” which is the mammalian homologue of all the three tissues in insects. Over expressing PPAR-γ in hepatocytes can induce adipocyte like features in hepatocytes. Similarly gene expression profile of macrophage is very similar to adipocytes. All the three cell systems are affected in disorders like NAFLD and obesity.